Endocytic pathway
1. LDL receptor
2. vesicle to endosome
3. receptor removed, recycled
4. CE hyrolyzed by acid lipase
5. Free chol removed somehow, mechanism poorly understood
6. lysosomes normally free of cholesterol

NPC2/NPC1
- NPC2 transports chol from internal membranes to NPC1(NTD)
 * or to membrane
 * NPC2 works also without NPC1
- NPC2/NPC1 interaction has been studied lately
- How NPC2 gets cholesterol?
 * membrane interactions, no penetration


LIPID role table
NPC2 mediated transport / fusion / spontaneous transport / fusion

BMP roles
- enhances cholesterol transport
- aka LBPA
- uniquely in endosome
- strange structure
 * resistant
- vesicle formation
- acid sphingomyelinase catalyst